Techniques and assays

Bioanalytical methods for research and discovery

UV, HPLC, LC-MS, LC-MSMS
Enzyme immunoassay (EIA) and Enzyme-linked immunosorbant assay (ELISA)Projects requiring other analytical methods, e.g. gas chromatography may be accommodated upon request

Bioanalysis for Drug Metabolism and Pharmacokinetic (DMPK) Studies

Blood/Plasma analysis
Tissue analysis
Other biofluids (urine, CSF, bile etc)

In-vitro ADME Assays

Absorption studies using PAMPA, CACO-2, PGP and other transporter enzyme assays
Metabolism studies using cyp450 enzymes, microsomes, S9, cytosol or hepatocytes
Distribution: protein binding (equilibrium dialysis), tissue binding
Inhibition: p450 inhibition

Sample Matrices

Biological, environmental, pharmaceuticals, food products.